MOLECULAR PHARMACOLOGY文献大全第25页

Two types of calcium-dependent protein phosphorylations modulated by calmodulin antagonists. Naphthalenesulfonamide derivatives.
abstract：:Ca2-dependent protein phosphorylations activated by calmodulin or phospholipid were studied using selective inhibitors. Both protein phosphorylations were inhibited by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives. Kinetic analysis indicated that the primary effect of these agents was me...

journal_title：Molecular pharmacology

pub_type： 杂志文章

doi：

authors： Tanaka T,Ohmura T,Yamakado T,Hidaka H

更新日期：1982-09-01 00:00:00
Characterization of variant neuroblastoma clones with missing or altered sodium channels.
abstract：:Variant neuroblastoma cell clones were selected for resistance to the cytotoxic effects of neurotoxins that cause persistent activation of sodium channels. Three classes of variant clones were obtained: sodium channel-deficient clones, which have markedly reduced numbers of functional sodium channels; scorpion toxin-r...

journal_title：Molecular pharmacology

pub_type： 杂志文章

doi：

authors： Costa MR,Catterall WA

更新日期：1982-07-01 00:00:00
Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards.
abstract：:A Walker 256 rat carcinoma cell line (WR) has been shown to be resistant to a broad spectrum of bifunctional nitrogen mustards (NM) in cell culture. The parent cell line (WS) from which the WR cells were selected retains marked sensitivity to this class of drugs. Karyotype analysis showed that the parent WS had a chro...

journal_title：Molecular pharmacology

pub_type： 杂志文章

doi：

authors： Tew KD,Wang AL

更新日期：1982-05-01 00:00:00
Characterization of serotonin uptake in cultured pheochromocytoma cells. Comparison with norepinephrine uptake.
abstract：:PC-12 cells, derived from a rat pheochromocytoma, were found to take up tritiated serotonin ([3H]5-HT) from the external medium by means of a saturable mechanism which follows Michaelis-Menten kinetics. The apparent Km of uptake was 0.39 microM and the Vmax was 0.40 pmole/min/10(6) cells. The uptake was temperature-de...

journal_title：Molecular pharmacology

pub_type： 杂志文章

doi：

authors： Yoffe JR,Borchardt RT

更新日期：1982-03-01 00:00:00
Structure of the saxitoxin binding site at sodium channels in nerve membranes. Exchange of tritium from bound toxin molecules.
abstract：:The exchange of tritium into water from saxitoxin molecules that were radiolabeled at the C-11 methylene position was measured at 37 degrees in solution and in suspensions of brain membranes. High concentrations of membrane receptors were used to assure that more than 80% of the total saxitoxin (STX) present was speci...

journal_title：Molecular pharmacology

pub_type： 杂志文章

doi：

authors： Strichartz G

更新日期：1982-03-01 00:00:00
Structure-activity relationships in the ansamycins. Molecular structure and activity of 3-carbomethoxy rifamycin S.
abstract：:The X-ray and NMR structural study of 3-carbomethoxy rifamycin S5 was undertaken in order to determine whether its low antimicrobial activity was related to a conformation of the molecule which was unfavorable for interaction with bacterial DNA-dependent RNA polymerase. However, the molecule assumes a conformation sim...

journal_title：Molecular pharmacology

pub_type： 杂志文章

doi：

authors： Brufani M,Cellai L,Cerrini S,Fedeli W,Segre A,Vaciago A

更新日期：1982-03-01 00:00:00

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